Development of calcium pectinate-tamarind seed polysaccharide mucoadhesive beads containing metformin HCl

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• 作者：Amit Kumar Nayak ; Dilipkumar Pal ; Kousik Santra
• 关键词：Tamarind seed polysaccharide ; Pectin ; Ionotropic-gelation ; Mucoadhesion ; Controlled drug release ; Metformin HCl
• 刊名：Carbohydrate Polymers
• 出版年：30 January, 2014
• 年：2014
• 卷：101
• 期：Complete
• 页码：220-230
• 全文大小：2445 K

文摘

Novel mucoadhesive beads containing metformin HCl made of low methoxy (LM) pectin-tamarind seed polysaccharide (TSP) polymer-blend was developed through ionotropic-gelation technique and optimized using 3² factorial design. Effects of LM pectin and TSP amounts on drug encapsulation efficiency (DEE), and cumulative drug release at 10 h (R_10h) were analyzed using response surface methodology. The optimized calcium pectinate-TSP beads containing metformin HCl showed DEE of 95.12 卤 4.26%, R_10h of 46.53 卤 3.28%, and mean diameter of 1.93 卤 0.26 mm. The in vitro drug release from these beads was followed controlled-release (zero-order) pattern with super case-II transport mechanism. These beads were also characterized by SEM and FTIR. The optimized beads also exhibited pH-dependent swelling, good mucoadhesivity with goat intestinal mucosa and significant hypoglycemic effect in alloxan-induced diabetic rats over prolonged period after oral administration.