Re-expression of cell cycle markers in aged neurons and muscles: Whether cells should divide or die?

详细信息    查看全文

• 作者：Renu Sharma ; Dhiraj Kumar ; Niraj Kumar Jha ; Saurabh Kumar Jha ; Rashmi K Ambasta ; Pravir Kumarp> ; p>p>pravirkumar@dce.edup>p> ; p>p>kpravir@gmail.comp>
• 关键词：Post-mitotic cell division ; Signaling cascade ; Neuromuscular degeneration ; Cyclins ; Therapeutics
• 刊名：Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：1863
• 期：1
• 页码：324-336
• 全文大小：1343 K
• 卷排序：1863

文摘

Cyclin/CDKs mediated cell cycle homeostasis and re-expression of cyclins in response to stress. Potential triggering factors that force mature neuron and muscles to re-enter into cell division post-mitotically Altered signal transduction cascade, which causes disruption in cell cycle homeostasis Post-mitotic cell division in the progression of AD, PD, HD, ALS and IBM diseases Therapeutic strategies using cell cycle inhibitors, chaperones, UbE3 ligase for the reversal of aberrant cell cycle entry