文摘
Cyclin/CDKs mediated cell cycle homeostasis and re-expression of cyclins in response to stress. Potential triggering factors that force mature neuron and muscles to re-enter into cell division post-mitotically Altered signal transduction cascade, which causes disruption in cell cycle homeostasis Post-mitotic cell division in the progression of AD, PD, HD, ALS and IBM diseases Therapeutic strategies using cell cycle inhibitors, chaperones, UbE3 ligase for the reversal of aberrant cell cycle entry