Activation and blockade of serotonin6 receptors in the dorsal hippocampus enhance T maze and hole-board performance in a unilateral 6-hydroxydopamine rat model of Parkinson's disease
详细信息 查看全文
- 作者：Kun Cheng Liua ; Jun Yi Lia ; Wen Xieb ; Li Bo Lic ; Jin Zhangb ; Cheng Xue Dub ; Yu Ming Zhangb ; Hui Hui Tanc ; Hui Sheng Wangb ; Li Zhangb ; zhangli1998@mail.xjtu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Dorsal hippocampus ; 5-HT6 receptors ; Memory ; Parkinson's disease ; Rat
- 刊名：Brain Research
- 出版年：2016
- 出版时间：1 November 2016
- 年：2016
- 卷：1650
- 期：Complete
- 页码：184-195
- 全文大小：853 K
文摘
- •
Intra-DH injection of 5-HT6 antagonist enhanced the memory functions in sham rats.
- •
Both 5-HT6 agonist and antagonist enhanced the memory functions in parkinsonian rats.
- •
5-HT6 antagonist increased DA and NA levels in several brain regions in sham rats.
- •
5-HT6 agonist and antagonist changed DA and NA levels in parkinsonian rats.
- •
5-HT6 agonist and antagonist did not change 5-HT levels in sham and parkinsonian rats.