Eaton’s reagent-mediated metal-free and efficient synthesis of NH-sulfoximines

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• 作者：Jianping Wang^a ; Jian Zhang^b ; Kun Miao^a ; Hongying Yun^a ; Hong C. Shen^a ; Weili Zhao^b ; Chungen Liang^a ; ^{Chungen.liang@roche.com}
• 关键词：Eaton&rsquo ; s reagent ; Sulfoximine ; Sodium azide ; Metal-free synthesis
• 刊名：Tetrahedron Letters
• 出版年：2017
• 出版时间：25 January 2017
• 年：2017
• 卷：58
• 期：4
• 页码：333-337
• 全文大小：663 K
• 卷排序：58

文摘

A simple, reliable and metal-free method for the synthesis of a variety of NH-sulfoximines was developed. The imination reaction can be carried out under reasonably mild conditions, and it requires an easy work-up. This method has been applied to highly functionalized sulfoxides with good yields.