Thermo-sensitive injectable hydrogel based on the physical mixing of hyaluronic acid and Pluronic F-127 for sustained NSAID delivery
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- 作者：Young-seok Jung ; Ph.D.a ; 1 ; Wooram Park ; Ph.D.a ; 1 ; Hyejin Parka ; Deok-Keun Leeb ; Kun Na ; Ph.D.a ; kna6997@catholic.ac.kr" class="auth_mail" title="E-mail the corresponding author
- 关键词：Hyaluronic acid (HA) ; Thermo-sensitive hydrogel ; Pluronic F-127 ; NSAID ; Arthritis
- 刊名：Carbohydrate Polymers
- 出版年：2017
- 出版时间：20 January 2017
- 年：2017
- 卷：156
- 期：Complete
- 页码：403-408
- 全文大小：1640 K
文摘
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An injectable thermo-sensitive hydrogel was prepared by a simple mixing of HA and Pluronic F-127.
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HA enhanced the mechanical strength of hydrogel and elicited a sustained release.
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In an animal model, the bioavailability of the drug was significantly improved.