文摘
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Summary
Protein kinase Cs play important roles in many biological processes and tumorigenesis. This study examined the expression of protein kinase C¦È and assessed its significance in patients with oral squamous cell carcinoma. Immunohistochemical staining was carried out to investigate the expression of protein kinase C¦È in 59 cases of oral squamous cell carcinoma. The results were correlated with clinical characteristics and outcome of patients. Diffuse cytoplasmic protein kinase C¦È was identified in 53 (89.8 % ) of the 59 oral squamous cell carcinoma cases, and the expression was not statistically associated with any clinicopathologic parameter. Twenty (40.7 % ) of the 59 oral squamous cell carcinoma cases exhibited nuclear expression of protein kinase C¦È with different grade of intensity. ¦Ö2 analysis indicated that high nuclear protein kinase C¦È expression correlated significantly with shorter 24-month survival (P = .043) and disease recurrence (P = .019). The Kaplan-Meier method also showed that high nuclear expression of protein kinase C¦È was significantly associated with poor overall survival (P = .034) and shorter time to recurrence (P = .003). Univariate analysis revealed that high nuclear protein kinase C¦È expression (P = .046; hazard ratio, 2.2), tumor size less than 2 cm (P = .049; hazard ratio, 4.7), lymph node metastasis (P = .003; hazard ratio, 3.0), and higher stage (P = .002; hazard ratio, 8.7) were each associated with shorter overall survival. We identified the aberrant nuclear expression of protein kinase C¦È in oral squamous cell carcinoma. High nuclear protein kinase C¦È expression may correlate with disease recurrence and poor survival in patients with oral squamous cell carcinoma.
