Measurement and correlation of solubilities of the poorly water-soluble pharmaceutical compound etodolac by addition of co-solvents
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- 作者：Yuma Naito ; Hiroyuki Matsuda ; Kazuya Shimomura ; Kiyofumi Kurihara ; Katsumi Tochigi ; Kazuo Tomono
- 关键词：Solubility ; Poorly water-soluble pharmaceutical ; Co-solvent ; Cyclodextrin
- 刊名：Fluid Phase Equilibria
- 出版年：2013
- 出版时间：15 November, 2013
- 年：2013
- 卷：357
- 期：Complete
- 页码：43-49
- 全文大小：593 K
文摘
The purpose of this study is to measure the solubilities of poorly water-soluble drugs, and to enhance their solubilities by adding co-solvents. Etodolac, a cyclooxygenase-2 (cox-2) inhibitor in non-steroid anti-inflammatory drugs (NSAIDs), was selected as a model pharmaceutical compound. The solubilities of etodolac were determined at 298.15 K in mixtures of water and the following six cyclodextrins (CDs) using high-performance liquid chromatography: ¦Á-CD, ¦Â-CD, ¦Ã-CD, 2-hydroxypropyl-¦Â-CD, 2-hydroxyethyl-¦Â-CD, and methyl-¦Â-CD. With the exception of ¦Ã-CD, the experimental solubility data were correlated using a modified Chrastil model. Additionally, the solubilization power of each correlated co-solvent-solute system was evaluated using a log-linear model. Finally, the stability constants were determined using the Takeru Higuchi-Connors solubility method.