Roles of exosomes and microvesicles in disease pathogenesis

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• 作者：Shin-ichiro Ohno ; Akio Ishikawa ; Masahiko Kuroda ; ^{kuroda@tokyo-med.ac.jp}
• 关键词：Exosome ; Microvesicle ; Morphology ; Immunology ; Infectious disease ; Neurological disease
• 刊名：Advanced Drug Delivery Reviews
• 出版年：2013
• 出版时间：March, 2013
• 年：2013
• 卷：65
• 期：3
• 页码：398-401
• 全文大小：245 K

文摘

A variety of cells release membrane vesicles, such as exosomes and microvesicles (MVs), that are thought to play key roles in cell-cell communication, antigen presentation, and the spread of infectious agents throughout the body. There have been considerable efforts to use MVs as diagnostic or prognostic markers because their composition is reflective of minor physiological changes. Furthermore, recent studies demonstrate that MVs derived from infected cells and tumors contribute to disease pathogenesis. This review presents an overview of the potential roles of MVs with respect to clinical diagnosis and disease pathogenesis.