Assessment of severity of leukoaraiosis: a diffusional kurtosis imaging study

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• 作者：Shuhui Xu^a ; Deqiu Ye^a ; Tao Lian^a ; Jianzhong Cai^b ; Zebin Xiao^c ; Yongchu Huang^a ; Xiangrong Chen^a ; ^{2310611338@qq.com" class="auth_mail" title="E-mail the corresponding author} ; Zhongping Zhang^d
• 关键词：Diffusion ; Kurtosis ; DKI ; Non-Gaussians ; Leukoaraiosis
• 刊名：Clinical Imaging
• 出版年：2016
• 出版时间：July-August 2016
• 年：2016
• 卷：40
• 期：4
• 页码：732-738
• 全文大小：584 K

文摘

The objective was to investigate the capabilities of diffusional kurtosis imaging (DKI) in detection of age-related white matter (WM) changes in elderly patients with leukoaraiosis.

Material and methods

Fractional anisotropy (FA), kurtosis, and diffusion parameters in the frontal lobe and parietal lobe were compared between 14 patients at Fazekas scale 0 and 1, and 15 patients at Fazekas scale 2 and 3.

Results

FA and DKI parameters were significantly altered in the ischemic lesions vs normal regions of WM in the severe patients.

Conclusion

DKI can provide sensitive imaging biomarkers for assessing the severity of leukoaraiosis in reference to Fazekas score.