Kv3.3 Channels Bind Hax-1 and Arp2/3 to Assemble a Stable Local Actin Network that Regulates Channel Gating
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- 作者：Yalan Zhang1 ; 9 ; Xiao-Feng Zhang6 ; 9 ; Matthew R. Fleming1 ; Anahita Amiri3 ; Lynda El-Hassar1 ; Alexei A. Surguchev1 ; Callen Hyland6 ; David P. Jenkins1 ; Rooma Desai1 ; Maile R. Brown1 ; Valeswara-Rao Gazula1 ; Michael F. Waters7 ; Charles H. Large8 ; Tamas L. Horvath5 ; Dhasakumar Navaratnam4 ; Flora M. Vaccarino3 ; Paul Forscher6 ; paul.forscher@yale.edu" class="auth_mail" title="E-mail the corresponding author ; Leonard K. Kaczmarek1 ; 2 ; leonard.kaczmarek@yale.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell
- 出版年：2016
- 出版时间：7 April 2016
- 年：2016
- 卷：165
- 期：2
- 页码：434-448
- 全文大小：4075 K
文摘
- 10">
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10">Kv3.3 ion channels coordinate assembly of Arp2/3-dependent cortical actin networks
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15">These actin networks slow the rate of Kv3.3 channel closing during depolarization
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Network assembly is coordinated by Hax-1, a Rac- and cortactin-binding protein
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Cerebellar ataxia is correlated with a channel mutation that blocks network assembly