Toyocamycin induces apoptosis via the crosstalk between reactive oxygen species and p38/ERK MAPKs signaling pathway in human prostate cancer PC-3 cells

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• 作者：Sul-Gi Park^a ; ¹ ; Sang-Hun Kim^a ; ¹ ; Kwang-Youn Kim^b ; ¹ ; Sun-Nyoung Yu^a ; Hyeun-Deok Choi^a ; Young-Wook Kim^a ; Hyo-Won Nam^a ; Young-Kyo Seo^c ; Soon-Cheol Ahn^a ; ^{ahnsc@pusan.ac.kr}
• 关键词：Toyocamycin ; Apoptosis ; Reactive oxygen species ; Extracellular signal-regulated kinases
• 刊名：Pharmacological Reports
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：69
• 期：1
• 页码：90-96
• 全文大小：1502 K
• 卷排序：69

文摘

Toyocamycin induces apoptosis via mitochondrial pathway. ROS plays an important role in Toyocamycin-induced apoptosis. Toyocamycin promotes p38/ERK MAPK activation. Toyocamycin regulates ROS-mediated apoptosis by inhibition of p38 on ERK MAPK.