Efficacy of 2 Representative Topical Agents to Prevent Keloid Recurrence After Surgical Excision

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• 作者：Jin Yong Shin ; MD^&lowast ; ; Seok-Kweon Yun ; MD ; PhD^&dagger ; ; Si-Gyun Roh ; MD^&Dagger ; ; Nae-Ho Lee ; MD ; PhD^§ ; ; ^{psjbnu@gmail.com} ; Kyung-Moo Yang ; MD ; PhD^‖
• 刊名：Journal of Oral and Maxillofacial Surgery
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：75
• 期：2
• 页码：401.e1-401.e6
• 全文大小：637 K
• 卷排序：75

文摘

Keloids are difficult to remove successfully and there is no universally accepted treatment. After surgical excision of the keloid, there are various management methods for prevention of keloid recurrence, such as intralesional injection, radiation, and topical agents. A few studies have compared topical agents with other treatments. The aim of this study was to investigate effective topical agents for the prevention of recurrent keloid after surgical excision.Materials and MethodsEligible articles were sought using core databases, including Medline, Embase, and Cochrane databases, up to April 2016. The predictor variables were mitomycin C (MC) and imiquimod cream treatment after keloid excision. The outcome variable was keloid recurrence rate.ResultsThe search strategy identified 120 publications. After screening, 9 articles were selected for review. Articles were divided into 2 groups: MC and imiquimod cream. The recurrence rate after surgical excision in the MC group was estimated to be 16.5%, and that in the imiquimod cream group was estimated to be 24.7%.ConclusionIf intralesional injection or radiation is not available, then MC or imiquimod 5% cream could be an effective alternative in preventing keloid recurrence.