High-Frequency, Low-Intensity Pulsed Ultrasound Enhances Alveolar Bone Healing of Extraction Sockets in Rats: A Pilot Study

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• 作者：Kyung Lhi Kang^&lowast ; ; ^&dagger ; ; ^{periokkl@khu.ac.kr" class="auth_mail" title="E-mail the corresponding author} ; Eun-Cheol Kim^&dagger ; ; ^&Dagger ; ; Joon Bong Park^&lowast ; ; ^&dagger ; ; Jung Sun Heo^&dagger ; ; ^§ ; ; Yumi Choi^&lowast ;
• 关键词：Low-intensity pulsed ultrasound ; High frequency ; Tooth extraction socket healing ; Alveolar bone formation in rats
• 刊名：Ultrasound in Medicine & Biology
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：42
• 期：2
• 页码：493-502
• 全文大小：1580 K

文摘

Most studies of the beneficial effects of low-intensity pulsed ultrasound (LIPUS) on bone healing have used frequencies between 1.0 and 1.5 MHz. However, after consideration of ultrasound wave characteristics and depth of target tissue, higher-frequency LIPUS may have been more effective on superficially positioned alveolar bone. We investigated this hypothesis by applying LIPUS (frequency, 3.0 MHz; intensity, 30 mW/cm²) on shaved right cheeks over alveolar bones of tooth extraction sockets in rats for 10 min/d for 2 wk after tooth extraction; the control group (left cheek of the same rats) did not receive LIPUS treatment. Compared with the control group, the LIPUS group manifested more new bone growth inside the sockets on histomorphometric analysis (maximal difference = 2.5-fold on the seventh day after extraction) and higher expressions of osteogenesis-related mRNAs and proteins than the control group did. These findings indicate that 3.0-MHz LIPUS could enhance alveolar bone formation and calcification in rats.