A 3D-printed local drug delivery patch for pancreatic cancer growth suppression

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• 作者：Hee-Gyeong Yi^a ; ¹ ; Yeong-Jin Choi^b ; ¹ ; Kyung Shin Kang^c ; Jung Min Hong^c ; Ruby Gupta Pati^a ; Moon Nyeo Park^a ; In Kyong Shim^d ; Chan Mi Lee^d ; Song Cheol Kim^d ; ^e ; ^{drksc@amc.seoul.kr" class="auth_mail" title="E-mail the corresponding author} ; Dong-Woo Cho^a ; ^{dwcho@postech.ac.kr" class="auth_mail" title="E-mail the corresponding author}
• 关键词：5-FU ; 5-flurouracil ; PLGA ; poly(lactide-co-glycolide) ; PCL ; polycaprolactone ; MHDS ; multi-head deposition system ; SEM ; scanning electron microscope ; FT-IR ; Fourier transform infrared spectroscopy ; PBS ; phosphate buffered saline ; DMSO ; dimethyl sulfoxide ; MTS ; 5-(3-carboxymethoxyphenyl)-2-(4 ; 5-dimethylthiazoly)-3-(4-sulfophenyl)tetrazolium ; inner salt ; IC50 ; inhibitory concentration 50 ; hASC ; human adipose stem cell ; H&E ; hematoxylin and eosin ; i.v. ; intravenous ; s.d. ; standard deviation ; S ; V ; su
• 刊名：Journal of Controlled Release
• 出版年：2016
• 出版时间：28 September 2016
• 年：2016
• 卷：238
• 期：Complete
• 页码：231-241
• 全文大小：2369 K

文摘

Since recurrence and metastasis of pancreatic cancer has a worse prognosis, chemotherapy has been typically performed to attack the remained malignant cells after resection. However, it is difficult to achieve the therapeutic concentration at the tumor site with systemic chemotherapy. Numerous local drug delivery systems have been studied to overcome the shortcomings of systemic delivery. However, because most systems involve dissolution of the drug within the carrier, the concentration of the drug is limited to the saturation solubility, and consequently cannot reach the sufficient drug dose. Therefore, we hypothesized that 3D printing of a biodegradable patch incorporated with a high drug concentration would provide a versatile shape to be administered at the exact tumor site as well as an appropriate therapeutic drug concentration with a controlled release. Here, we introduce the 3D-printed patches composed of a blend of poly(lactide-co-glycolide), polycaprolactone, and 5-fluorouracil for delivering the anti-cancer drug in a prolonged controlled manner and therapeutic dose. 3D printing technology can manipulate the geometry of the patch and the drug release kinetics. The patches were flexible, and released the drug over four weeks, and thereby suppressed growth of the subcutaneous pancreatic cancer xenografts in mice with minimized side effects. Our approach reveals that 3D printing of bioabsorbable implants containing anti-cancer drugs could be a powerful method for an effective local delivery of chemotherapeutic agents to treatment of cancers.