Atypical femur fracture in an adolescent boy treated with bisphosphonates for X-linked osteoporosis based on PLS3 mutation
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- 作者：Denise M. van de Laarschot ; BSc ; M. Carola Zillikens ; MD ; PhD ; m.c.zillikens@erasmusmc.nl" class="auth_mail" title="E-mail the corresponding author
- 关键词：Osteoporosis ; Osteogenesis imperfecta ; X-linked osteoporosis ; Bisphosphonates ; Atypical femur fracture
- 刊名：Bone
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：91
- 期：Complete
- 页码：148-151
- 全文大小：510 K
文摘
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AFFs also occur in adolescents treated with bisphosphonates during childhood.
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AFF is for the first time reported in X-linked osteoporosis due to PLS3 mutation.
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A genetic predisposition may underlie AFF at least in some cases.
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Bisphosphonate-associated fractures may occur in other long bones beside the femur.
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The occurrence of AFFs should be considered in management of congenital bone disease.