NIPTL-Novo: Non-isobaric peptide termini labeling assisted peptide de novo sequencing

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• 作者：Shen Zhang^a ; ^b ; ^c ; ¹ ; Yichu Shan^a ; ¹ ; Shurong Zhang^a ; ¹ ; Zhigang Sui^a ; Lihua Zhang^a ; ^{lihuazhang@dicp.ac.cn} ; Zhen Liang^a ; Yukui Zhang^a
• 关键词：De novo sequencing ; Non-isobaric peptide termini labeling ; Quantitative proteomics ; Mass-defect based labeling ; Peptide mutation
• 刊名：Journal of Proteomics
• 出版年：2017
• 出版时间：10 February 2017
• 年：2017
• 卷：154
• 期：Complete
• 页码：40-48
• 全文大小：1690 K
• 卷排序：154

文摘

Non-isobaric peptide termini labeling will help to distinguish both b and y ion series. The quantitative profiling can be performed simultaneously along with the de novo sequencing. This strategy can be expanded to peptide mutation analysis with combination of mass-defect based labeling.