The age-dependent effects of a single-dose methylphenidate challenge on cerebral perfusion in patients with attention-deficit/hyperactivity disorder

详细信息    查看全文

• 作者：A Schrantee^a ; ^b ; ^{a.g.schrantee@amc.uva.nl} ; HJMM Mutsaerts^a ; ^c ; C Bouziane^a ; HGH Tamminga^a ; ^d ; MA Bottelier^e ; L Reneman^a ; ^b
• 关键词：ADHD ; Methylphenidate ; Dopamine ; Age ; Cerebral blood flow ; Arterial spin labeling
• 刊名：NeuroImage: Clinical
• 出版年：2017
• 出版时间：2017
• 年：2017
• 卷：13
• 期：Complete
• 页码：123-129
• 全文大小：692 K
• 卷排序：13

文摘

We examined the age-dependent effects of MPH on cerebral blood flow in ADHD patients. We included stimulant-treatment naive adolescent and adult male ADHD patients. Arterial spin labeling MRI was conducted before and after an acute MPH challenge. ROI analyses showed a decrease in thalamic CBF in children but not adults. Whole brain analyses showed widespread reduction in cortical CBF following MPH.