Cerebral blood flow measured by arterial spin labeling MRI at resting state in normal aging and Alzheimer’s disease

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• 作者：Nan Zhang^a ; ^b ; Marc L. Gordon^a ; ^c ; ^{MLGordon@northwell.edu} ; Terry E. Goldberg^a ; ^c ; ^{TGoldber@northwell.edu}
• 关键词：Arterial spin labeling ; Magnetic resonance imaging ; Cerebral blood flow ; Aging ; Mild cognitive impairment ; Alzheimer&rsquo ; s disease
• 刊名：Neuroscience & Biobehavioral Reviews
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：72
• 期：Complete
• 页码：168-175
• 全文大小：1285 K
• 卷排序：72

文摘

ASL MRI is a noninvasive method to quantitatively measure cerebral blood flow. Technical advances and multivariate statistical analysis improve ASL investigations. Cerebral blood flow changes in aging vary depending on vascular and AD risk factors. ASL is promising to use in early diagnosis and monitoring disease progression in AD.