Hepatitis E virus seroprevalence among schistosomiasis patients in Northeastern Brazil

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• 作者：Ana Maria Passos-Castilhop>ap> ; Anne de Senap>ap>p> ; p>p>bp> ; Ana Lucia Coutinho Dominguesp>dp> ; Edmundo Pessoa Lopes-Netop>dp> ; Tibé ; rio Batista Medeirosp>dp> ; Celso Francisco Hernandez Granatop>ap>p> ; p>p>bp> ; Maria Lú ; cia Ferrazp>cp>p> ; p>p>marialucia.ferraz@uol.com.br" class="auth_mail" title="E-mail the corresponding authorp>
• 关键词：Brazil ; Epidemiology ; Hepatitis E virus ; Schistosomiasis ; Seroprevalence
• 刊名：The Brazilian Journal of Infectious Diseases
• 出版年：2016
• 出版时间：May-June 2016
• 年：2016
• 卷：20
• 期：3
• 页码：262-266
• 全文大小：568 K

文摘

Hepatitis E virus (HEV) can cause chronic infection with rapid progression to liver cirrhosis in immunocompromised patients. HEV seroprevalence in patients with Schistosoma mansoni in Brazil is unknown. We evaluated the prevalence of past or present HEV infection in schistosomiasis patients in Recife, Pernambuco, Brazil. A total of 80 patients with Schistosoma mansoni were consecutively enrolled in a cross-sectional study. Serum samples were tested for the presence of anti-HEV IgG antibodies by enzyme immunoassay (Wantai anti-HEV IgG, Beijing, China) and for the presence of HEV RNA using real time reverse transcriptase-polymerase chain reaction with primers targeting the HEV ORF2 and ORF3. Clinical and laboratory tests as well as abdominal ultrasound were performed at the same day of blood collection.p>

Results

<p id="spar0035">Anti-HEV IgG was positive in 18.8% (15/80) of patients with SM. None of the samples tested positive for anti-HEV IgM or HEV-RNA. Patients with anti-HEV IgG positive presented higher levels of alanine aminotranferase (p = 0.048) and gama-glutamil transferase (p = 0.022) when compared to patients without anti-HEV IgG antibodies.p>

3">Conclusion

<p id="spar0040">This study demonstrates that the seroprevalence of HEV is high in patients with Schistosoma mansoni in Northeastern of Brazil. Past HEV infection is associated with higher frequency of liver enzymes abnormalities. HEV infection and its role on the severity of liver disease should be further investigated among patients with Schistosoma mansoni.