Analysis of a FANCE Splice Isoform in Regard to DNA Repair
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- 作者：Fré ; dé ; rick Bouffard ; Karine Plourde ; Simon Bé ; langer ; Geneviè ; ve Ouellette ; Yvan Labrie ; Francine Durocher ; francine.durocher@crchudequebec.ulaval.ca" class="auth_mail" title="E-mail the corresponding author
- 关键词：AS ; alternative splicing ; DMEM ; Dulbecco's modified Eagle's medium ; EDTA ; ethylenediaminetetraacetic acid ; ER ; estrogen receptor ; FA ; Fanconi anemia ; FACS ; fluorescence-activated cell sorting ; FBS ; fetal bovine serum ; ICL ; interstrand crosslink ; LCL ; lymphoblastoid cell line ; MMC ; mitomycin C ; NLS ; nuclear localization signal ; NMD ; nonsense-mediated decay ; NP-40 ; Nonidet-P40 ; PBS ; phosphate-buffered saline ; qPCR ; quantitative PCR ; qRT-PCR ; quantitative real-time PCR
- 刊名：Journal of Molecular Biology
- 出版年：2015
- 出版时间：25 September 2015
- 年：2015
- 卷：427
- 期：19
- 页码：3056-3073
- 全文大小：2157 K
文摘
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A novel alternative splicing event of the FANCE gene has been characterized.
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FANCE螖4 cannot support the activation of the FANC-BRCA pathway and DNA repair.
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FANCE螖4 tends to have a negative impact on FANCD2 protein expression.
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Three sequence variations can potentially modulate FANCE螖4/FANCE expression ratio.