Oxidants, nitric oxide and prostanoids in the developing ocular vasculature: a basis for ischemic retinopathy

详细信息    查看全文

• 作者：Hardy ; Pierre ; Dumont ; Isabelle ; Bhattacharya ; Mousumi ; Hou ; Xin ; Lachapelle ; Pierre ; Varma ; Daya R. ; et. al.
• 关键词：Blood flow ; Free radicals ; Nitric oxide ; Prostaglandins ; COX ; cyclooxygenase ; ChBF ; choroidal blood flow ; RBF ; retinal blood flow ; IP₃ ; inositol 1 ; 4 ; 5-triphosphate ; NO ; nitric oxide ; NOS ; nitric oxide synthase ; PG ; prostaglandin ; RBF ; retinal b
• 刊名：Cardiovascular Research
• 出版年：2000
• 出版时间：August 18, 2000
• 年：2000
• 卷：47
• 期：3
• 页码：489-509
• 全文大小：1.33 M

文摘

The choroid is the main source of oxygen to the retina. In contrast to the adult, the absence of autoregulation of choroidal blood flow in the newborn leads to hyperoxygenation of the retina. In the immature retina which contains relatively low levels of antioxidants this hyperoxygenation favors peroxidation including the generation of biologically active isoprostanes, and results in vasoconstriction and vascular cytotoxicity leading to ischemia, which predisposes to the development of a vasoproliferative retinopathy, commonly termed retinopathy of prematurity. During frequently encountered oxidative stress to the perinate, the combined absence of vascular autoregulation and excessive oxygen delivery to the eyes of the developing subject is largely the result of a complex epigenetic and genetic interplay between prostanoids and nitric oxide (NO) systems on vasomotor regulation. The effects of certain prostaglandins are NO-dependent; conversely, those of NO have also been found to be largely prostaglandin I₂-mediated in the eye; and NO synthase expression seems to be significantly regulated by other prostaglandins apparently through activation of functional perinuclear prostanoid receptors which affect gene transcription. The increased production of both prostaglandins and NO in the perinate augment ocular blood flow and as a result oxygen delivery to an immature retina partly devoid of antioxidant defenses. The ensuing peroxidation results in impaired circulation (partly thromboxane A₂-dependent) and vascular integrity, leading to ischemia which predisposes to abnormal preretinal neovascularization, a major feature of ischemic retinopathy. Because tissue oxygenation is largely dependent upon circulation and critical in the generation of reactive oxygen species, and since the latter exert a major contribution in the pathogenesis of retinopathy of prematurity, it is important to understand the mechanisms that govern ocular blood flow. In this review we focus on the important and complex interaction between prostanoid, NO and peroxidation products on circulatory control of the immature retina.