Menopausal quality of life: RCT of yoga, exercise, and omega-3 supplements

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• 作者：Susan D. Reed ; MD^a ; ^{reeds@u.washington.edu" class="auth_mail} ; Katherine A. Guthrie ; PhD^b ; Katherine M. Newton ; PhD^c ; Garnet L. Anderson ; PhD^b ; Cathryn Booth-LaForce ; PhD^d ; Bette Caan ; DrPH^f ; Janet S. Carpenter ; PhD^g ; Lee S. Cohen ; MD^h ; Andrea L. Dunn ; PhD^j ; Kristine E. Ensrud ; MD^k ; Ellen W. Freeman ; PhD^l ; Julie R. Hunt ; PhD^b ; Hadine Joffe ; MD^h ; ⁱ ; Joseph C. Larson ; MS^b ; Lee A. Learman ; MD^m ; Robin Rothenberg ; BS^e ; Rebecca A. Seguin ; PhD^b ; ⁿ ; Karen J. Sherman ; PhD^c ; Barbara S. Sternfeld ; PhD^f ; Andrea Z. LaCroix ; PhD^b
• 关键词：exercise ; menopause ; omega-3 ; quality of life ; randomized controlled trial ; yoga
• 刊名：American Journal of Obstetrics and Gynecology
• 出版年：March, 2014
• 年：2014
• 卷：210
• 期：3
• 页码：244.e1-244.e11
• 全文大小：798 K

文摘

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Objective

The purpose of this study was to determine the efficacy of 3 nonhormonal therapies for the improvement of menopause-related quality of life in women with vasomotor symptoms.

Study Design

We conducted a 12-week 3聽脳 2 randomized, controlled, factorial design trial. Peri- and postmenopausal women, 40-62 years old, were assigned randomly to yoga (n聽= 107), exercise (n聽= 106), or usual activity (n聽= 142) and also assigned randomly to a double-blind comparison of omega-3 (n聽= 177) or placebo (n聽= 178) capsules. We performed the following interventions: (1) weekly 90-minute yoga classes with daily at-home practice, (2) individualized facility-based aerobic exercise training 3 times/week, and (3) 0.615 g omega-3 supplement, 3聽times/day. The outcomes were assessed with the following scores: Menopausal Quality of Life Questionnaire (MENQOL) total and domain (vasomotor symptoms, psychosocial, physical and sexual).

Results

Among 355 randomly assigned women who average age was 54.7 years, 338 women (95%) completed 12-week assessments. Mean baseline vasomotor symptoms frequency was 7.6/day, and the mean baseline total MENQOL score was 3.8 (range, 1-8 from better to worse) with no between-group differences. For yoga compared to usual activity, baseline to 12-week improvements were seen for MENQOL total -0.3 (95% confidence interval, -0.6 to聽0; P聽= .02), vasomotor symptom domain (P聽= .02), and sexuality domain (P聽= .03) scores. For women who underwent exercise and omega-3 therapy compared with control subjects, improvements in baseline to 12-week total MENQOL scores were not observed. Exercise showed benefit in the MENQOL physical domain score at 12 weeks (P聽= .02).

Conclusion

All women become menopausal, and many of them seek medical advice on ways to improve quality of life; little evidence-based information exists. We found that, among healthy sedentary menopausal women, yoga appears to improve menopausal quality of life; the clinical significance of our finding is uncertain because of the modest effect.