Protein corona over silver nanoparticles triggers conformational change of proteins and drop in bactericidal potential of nanoparticles: Polyethylene glycol capping as preventive strategy
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- 作者：Deependra Kumar Ban ; Subhankar Paul ; spaul@nitrkl.ac.in" class="auth_mail" title="E-mail the corresponding author
- 关键词：Silver nanoparticles ; Bovine α-lactalbumin ; Protein corona ; Bactericidal potential ; Hemocompatibility
- 刊名：Colloids and Surfaces B: Biointerfaces
- 出版年：2016
- 出版时间：1 October 2016
- 年：2016
- 卷：146
- 期：Complete
- 页码：577-584
- 全文大小：3347 K
文摘
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Silver nanoparticles (AgNPST) readily interact with bovine α-lactalbumin (BLA).
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Such protein-AgNP interaction causes functional and conformational change of BLA.
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Protein corona over AgNPST reduced inherent antibacterial potential of nanoparticle.
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Polyethylene glycol (PEG)-capped AgNP prevents the conformational change of protein.
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PEG-capped AgNP retain its antibacterial potential and show better hemocompatibility.