Silver nanoparticles (AgNPST) readily interact with bovine α-lactalbumin (BLA).
Such protein-AgNP interaction causes functional and conformational change of BLA.
Protein corona over AgNPST reduced inherent antibacterial potential of nanoparticle.
Polyethylene glycol (PEG)-capped AgNP prevents the conformational change of protein.
PEG-capped AgNP retain its antibacterial potential and show better hemocompatibility.