The metabolic trinity, glucose-glycogen-lactate, links astrocytes and neurons in brain energetics, signaling, memory, and gene expression
文摘
Glucose, glycogen, and lactate are involved in diverse aspects of brain function. Fate of surplus carbohydrate taken up into brain during exercise is unexplained. Glucose and lactate enhance memory; glycogen is required for its consolidation. High-dose lactate preserves memory and gene expression without glycogenolysis. High-dose lactate suppresses neuronal firing and is taken up mainly by astrocytes.