Poly(lactic acid) based hydrogels

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• 作者：Arijit Basu^a ; ^{arijitb@ekmd.huji.ac.il} ; Konda Reddy Kunduru^a ; Sindhu Doppalapudi^b ; Abraham J. Domb^a ; ^{avid@ekmd.huji.ac.il} ; Wahid Khan^b
• 关键词：PLA ; poly(lactic acid) ; PDLA ; poly(D-lactic acid) ; PLLA ; poly(L-lactic acid) ; PLGA ; poly(lactide-co-glycolide) or poly(D ; L-lactide-co-glycolide) ; PEG ; poly(ethylene glycol) ; DCC ; dicyclohexylcarbodiimide ; PEOz ; poly (2-ethyl-2-oxazoline) ; EPR ; enhanced permeability and retention ; Tgf-β1 ; transforming growth factor beta 1 ; PCLA ; poly(ε-caprolactone-co-lactide) ; RGD ; arginine&ndash ; glycine&ndash ; aspartate ; PCL ; polycaprolactone ; PUs ; polyurethanes ; PLAUs ; PLA based PUs ; PEO ; poly(ethylene oxide)
• 刊名：Advanced Drug Delivery Reviews
• 出版年：2016
• 出版时间：15 December 2016
• 年：2016
• 卷：107
• 期：Complete
• 页码：192-205
• 全文大小：1640 K
• 卷排序：107

文摘

Polylactide (PLA) and its copolymers are hydrophobic polyesters used for biomedical applications. Hydrogel medicinal implants have been used as drug delivery vehicles and scaffolds for tissue engineering, tissue augmentation and more. Since lactides are non-functional, they are copolymerized with hydrophilic monomers or conjugated to a hydrophilic moiety to form hydrogels. Copolymers of lactic and glycolic acids with poly(ethylene glycol) (PEG) provide thermo-responsive hydrogels. Physical crosslinking mechanisms of PEG–PLA or PLA-polysaccharides include: lactic acid segment hydrophobic interactions, stereocomplexation of D and L-lactic acid segments, ionic interactions, and chemical bond formation by radical or photo crosslinking. These hydrogels may also be tailored as stimulus responsive (pH, photo, or redox). PLA and its copolymers have also been polymerized to include urethane bonds to fabricate shape memory hydrogels. This review focuses on the synthesis, characterization, and applications of PLA containing hydrogels.