Effect of microencapsulated precipitants of Lactobacillus casei ATCC 393 on Helicobacter pylori eradication

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• 作者：J.A. Ko^a ; ¹ ; H.J. Lim^a ; ^b ; ¹ ; H.J. Park^a ; ^c ; ^{hjpark@korea.ac.kr}
• 关键词：Lactobacillus casei ATCC 393 ; Helicobacter pylori ; Chitosan ; Poly-γ ; -glutamic ; Microspheres
• 刊名：Process Biochemistry
• 出版年：2011
• 出版时间：March 2011
• 年：2011
• 卷：46
• 期：3
• 页码：631-635
• 全文大小：261 K

文摘

Precipitants of Lactobacillus casei ATCC 393-loaded chitosan microspheres were prepared by electrostatic interaction between chitosan (CS) and poly-γ-glutamic acid (γ-PGA). The loading efficiency was approximately 80 % , and the zeta potential of the microspheres became more positively charged as the molar ratio of the chitosan amino group was increased. The particles were confirmed to have a spherical shape by optical microscopy. A release test using simulated gastric fluid (SGF) was also performed. The results show that the precipitants were gradually released from the CS-γ-PGA microspheres at a rate of almost 80 % after 60 min. Both the inhibition of Helicobacter pylori growth and the anti-adhesive activity of encapsulated precipitants were maintained after exposure to SGF. These results indicate that CS-γ-PGA microspheres may provide a delivery system for the effective eradication of H. pylori.