Lactoferrin nanoparticle mediated targeted delivery of 5-fluorouracil for enhanced therapeutic efficacy

详细信息    查看全文

• 关键词：Targeted drug delivery ; Lactoferrin nanoparticle ; Fluorouracil ; Melanoma ; pH responsive
• 刊名：International Journal of Biological Macromolecules
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：95
• 期：Complete
• 页码：232-237
• 全文大小：1201 K
• 卷排序：95

文摘

Narrow size distribution with a high encapsulation efficiency. Stable for long term, biocompatible and safe delivery vehicle. Lactoferrin receptor mediated endocytosis and lysosomal co localization. PH responsive drug release. Prolonged intracellular retention and enhanced anticancer effect of 5-FU-LfNPs compare to the free 5-FU.