Highly Collapsed Conformation of the Initial Folding Intermediates of 尾-Lactoglobulin with Non-Native 伪-Helix
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- 作者：Tsuyoshi Konuma1 ; 6 ; Kazumasa Sakurai2 ; Masanori Yagi1 ; 7 ; Yuji Goto1 ; Tetsuro Fujisawa3 ; 4 ; Satoshi Takahashi5 ; st@tagen.tohoku.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：SF ; stopped-flow ; CF ; continuous-flow ; 尾LG ; 尾-lactoglobulin ; TFE ; 2 ; 2 ; 2-trifluoroethanol ; SAXS ; small-angle X-ray scattering ; H/D ; hydrogen/deuterium
- 刊名：Journal of Molecular Biology
- 出版年：2015
- 出版时间：25 September 2015
- 年：2015
- 卷：427
- 期：19
- 页码：3158-3165
- 全文大小：513 K
文摘
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Folding of 尾LG involves intermediates with non-native 伪-helix.
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Submillisecond dynamics of 尾LG folding was observed with CD and SAXS.
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Initial collapse occurs irrespective of the contents of non-native 伪-helices.
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Non-native helix around strand A might facilitate long-range contact formation.