Synthesis and reactions of sulfur-substituted 伪,尾-unsaturated 未-聽and聽纬-lactones

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• 作者：Shang-Shing P. Chou ; Wan-Shiuan Wu
• 关键词：Aza-Diels&ndash ; Alder reaction ; Allylic bromides ; Intramolecular cyclization ; 伪 ; 尾-Unsaturated 未-lactones ; 伪 ; 尾-Unsaturated 纬-lactones
• 刊名：Tetrahedron
• 出版年：11 March, 2014
• 年：2014
• 卷：70
• 期：10
• 页码：1847-1854
• 全文大小：1443 K

文摘

A new synthetic method for the preparation of sulfur-substituted 伪,尾-unsaturated 未- and 纬-lactones has been developed by reaction of the allylic bromides of 5,6-dihydro-2-pyridinones with NaOH in refluxing MeOH or t-BuOH. The substituents at C5 and C6 of these substrates are very important for the success of this reaction. Some synthetic transformations of the 伪,尾-unsaturated 未-lactones have also been carried out.