Synthesis and anticancer activity of novel halolactones with 尾-aryl substituents from simple aromatic aldehydes
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- 作者：Witold G艂adkowski ; Andrzej Skrobiszewski ; Marcelina Mazur ; Monika Siepka ; Aleks ; ra Pawlak ; Bo偶ena Obmi艅ska-Mrukowicz ; Agata Bia艂o艅ska ; Dominik Poradowski ; Angelika Drynda ; Mariusz Urbaniak
- 关键词：Lactones ; Aromatic ring ; Halolactonization ; Cytotoxic activity
- 刊名：Tetrahedron
- 出版年：2 December, 2013
- 年：2013
- 卷：69
- 期：48
- 页码：10414-10423
- 全文大小：648 K
文摘
A series of 20 novel racemic iodo-, bromo- and chlorolactones, possessing 尾-phenyl-纬-lactone or 尾-phenyl-未-lactone framework, were synthesized from commercially available aromatic aldehydes in convenient five-step syntheses. Some of them showed noticeable cytotoxic effect against two cancer lines, Jurkat (human leukaemia) and D17 (canine osteosarcoma). The highest activity, comparable with carboplatin, was observed for cis-5-(1-iodoethyl)-4-(4鈥?isopropylphenyl)dihydrofuran-2-one against Jurkat cell line.