Sesquiterpene lactones from Smyrnium olusatrum

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• 作者：El-Gamal ; Ali A.
• 关键词：Smyrnium olusatrum ; Apiaceae ; Sesquiterpenes ; Eudesmen-8α ; 12-olide ; Glechomanolides ; Cytotoxic activity
• 刊名：Phytochemistry
• 出版年：2001
• 出版时间：August, 2001
• 年：2001
• 卷：57
• 期：8
• 页码：1197-1200
• 全文大小：114 K

文摘

Fruits of Smyrnium olusatrum afforded three sesquiterpene lactones, namely, 1β,8β-dihydroxyeudesman-3,7(11)-dien-8α,12-olide, 1β,8β-dihydroxyeudesman-4(15),7(11)-dien-8α,l2-olide, and 1β,10α,4α,5β-diepoxy-6β-hydroxyglechoman-8α,12-olide. Four related known sesquiterpenes were also isolated and characterized. The structure elucidation of the isolated compounds was based primarily on 1D and 2D NMR analyses. The in vitro cytotoxicity of the extract and isolated compounds against P-388 mouse lymphoma cells will be also discussed.