Gestational hypertension, preeclampsia and intrauterine growth restriction induce dysregulation of cardiovascular and cerebrovascular disease associated microRNAs in maternal whole peripheral blood
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- 作者：Ilona Hromadnikovaa ; ilona.hromadnikova@lf3.cuni.cz" class="auth_mail" title="E-mail the corresponding author ; Katerina Kotlabovaa ; kotlabova.k@seznam.cz" class="auth_mail" title="E-mail the corresponding author ; Lucie Hympanovaa ; b ; Lucie.Hympanova@seznam.cz" class="auth_mail" title="E-mail the corresponding author ; Ladislav Kroftab ; ladislav.krofta@upmd.cz" class="auth_mail" title="E-mail the corresponding author
- 关键词：Cardio/cerebrovascular diseases ; Gestational hypertension ; Intrauterine growth restriction ; MicroRNA ; Preeclampsia
- 刊名：Thrombosis Research
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：137
- 期：Complete
- 页码：126-140
- 全文大小：1863 K
文摘
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Down-regulation of miR-100-5p, miR-125b-5p and miR-199a-5p is present in GH, PE and IUGR.
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Moreover, IUGR is associated with down-regulation of miR-17-5p, miR-146a-5p, miR-221-3p and miR-574-3p.
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Preeclampsia terminated before 34 weeks was associated with down-regulation of miR-146a-5p, miR-199a-5p and miR-221-3p.
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Aberrant expression of miR-146a-5p and miR-221-3p appears in most severe preeclampsia and IUGR.
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Epigenetic changes may cause later onset of cardiovascular diseases in the mother.