Effects of genetic consultation on perception of a family risk of breast/ovarian cancer and determinants of inaccurate perception after the consultation
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- 作者：Huiart ; Laetitia ; Eisinger ; Franç ; ois ; Stoppa-Lyonnet ; Dominique ; Lasset ; Christine ; et. al.
- 关键词：Risk perception ; BRCA genes ; Cancer genetic services
- 刊名：Journal of Clinical Epidemiology
- 出版年：2002
- 出版时间：July, 2002
- 年：2002
- 卷：55
- 期：7
- 页码：665-675
- 全文大小：356 K
文摘
The aim of this study was to assess the effects of cancer genetic consultations on women's perception of their family risk of breast/ovarian cancer, and to determine which factors were associated with an inaccurate perception after the consultation. A multicenter prospective survey was carried out on women (n = 397) attending cancer genetic clinics in France for the first time, in which the perceived family risk was measured both before and after the consultation, using self-administered questionnaires. The effects of the consultation on risk perception were significant among low (P < .001) and moderate risk women (P < .05). However, after the consultation, 76.3 % of the “low”-risk women did not perceive their family as “low”-risk families, and 21.9 % of the moderate-risk women were still definitely sure there was a genetic risk running in their family. The consultation did not affect the family risk perception of the high risk women (n = 171): the risk was thought to be very high both before (87.7 % ) and after (89.5 % ) the consultation (NS); however 10.5 % of this group still perceived their family as being unlikely to be at risk after the consultation. In the low- and moderate-risk groups after multivariate adjustment, the inaccurate perceptions varied, depending on the clinics and on the psychosocial context of the consultation: they increased when the consultee was personally affected by cancer, and decreased when the consultee had a health occupation. Cancer genetic consultations had only marginal effects on the perception of family risk on the whole, although they were significant in the case of low- and moderate-risk women. The question arises as to whether a more comprehensive approach should be implemented and how to go about providing efficient cancer risk information in the context of health care systems.