Systems Scale Interactive Exploration Reveals Quantitative and Qualitative Differences in Response to Influenza and Pneumococcal Vaccines

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• 作者：Gerlinde Obermoser¹ ; Scott Presnell² ; Kelly Domico² ; Hui Xu³ ; Yuanyuan Wang¹ ; Esperanza Anguiano¹ ; LuAnn Thompson-Snipes¹ ; Rajaram Ranganathan¹ ; Brad Zeitner² ; Anna Bjork² ; David Anderson² ; Cate Speake² ; Emily Ruchaud¹ ; Jason Skinner¹ ; Laia Alsina¹ ; Mamta Sharma¹ ; Helene Dutartre¹ ; Alma Cepika¹ ; Elisabeth Israelsson² ; Phuong Nguyen¹ ; Quynh-Anh Nguyen¹ ; A. Carson Harrod¹ ; Sandra M. Zurawski¹ ; Virginia Pascual¹ ; Hideki Ueno¹ ; Gerald T. Nepom² ; Charlie Quinn¹ ; ² ; Derek Blankenship³ ; Karolina Palucka¹ ; ^{karolinp@baylorhealth.edu} ; Jacques Banchereau¹ ; Damien Chaussabel¹ ; ² ; ^{dchaussabel@benaroyaresearch.org}
• 刊名：Immunity
• 出版年：2013
• 出版时间：18 April, 2013
• 年：2013
• 卷：38
• 期：4
• 页码：831-844
• 全文大小：3133 K

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Summary

Systems immunology approaches were employed to investigate innate and adaptive immune responses to influenza and pneumococcal vaccines. These two non-live vaccines show different magnitudes of transcriptional responses at different time points after vaccination. Software solutions were developed to explore correlates of vaccine efficacy measured as antibody titers at day 28. These enabled a further dissection of transcriptional responses. Thus, the innate response, measured within hours in the peripheral blood, was dominated by an interferon transcriptional signature after influenza vaccination and by an inflammation signature after pneumococcal vaccination. Day 7 plasmablast responses induced by both vaccines was more pronounced after pneumococcal vaccination. Together, these results suggest that comparing global immune responses elicited by different vaccines will be critical to our understanding of the immune mechanisms underpinning successful vaccination.