Multivariate optimization of a digestion procedure for bismuth determination in urine using continuous flow hydride generation and atomic fluorescence spectrometry
Multivariate designs were applied for evaluation and optimization of a urine digestion procedure to determine Bi by HG AFS. A robust, efficient and simple alternative for urine digestion using "cold finger" reflux systems was proposed. Analytical method for the determination of bismuth in urine with adequate LOD and LOQ for the low concentration. The applicability of the method was investigated by analyzing of five urine samples.