The Gramicidin Pore: Selective Tryptophan Replacement with Aspartic Acid

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• 作者：Ranganathan ; Subramania ; Kundu ; Dinabandhu ; Tamilarasu ; Natarajan ; Nagaraj ; Ramakrishnan ; et. al.
• 刊名：Tetrahedron Letters
• 出版年：1996
• 出版时间：July 15, 1996
• 年：1996
• 卷：37
• 期：29
• 页码：5199-5202
• 全文大小：231 K

文摘

The chemoselective transformation of Trp⁹ and Trp¹¹, located at the hydrophobic core of the antiparallel, double helical pore of O-acetyl gramicidin A(HCO-ValGlyAlaLeu⁰AlaVal⁰ValVal⁰ TrpLeu⁰ TrpLeu⁰TrpLeu⁰TrpNHCH₂CH₂OAc; 0 = D isomer) to Asp⁹ gramicidin and Asp⁹ Asp¹¹ gramicidin has been demonstrated by oxidation with 0.25 eq. of in situ generated Ru(VIII), HPLC isolation, amino acid analysis and peptide sequencing.