Estimating the cure proportion of malignant melanoma, an alternative approach to assess long term survival: A population-based study

详细信息    查看全文

• 作者：Therese M.-L. Andersson ; Hanna Eriksson ; Johan Hansson ; Eva M氓nsson-Brahme ; Paul W. Dickman ; S ; ra Eloranta ; Mats Lambe ; Paul C. Lambert
• 关键词：Malignant melanoma ; Survival ; Cure ; Population-based ; Flexible parametric model ; Relative survival
• 刊名：Cancer Epidemiology
• 出版年：February, 2014
• 年：2014
• 卷：38
• 期：1
• 页码：93-99
• 全文大小：377 K

文摘

Objectives

A large proportion of patients with cutaneous malignant melanoma (CMM) do not experience excess mortality due to their disease. This group of patients is referred to as the cure proportion. Few studies have examined the possibility of cure for CMM. The aim of this study was to estimate the cure proportion of patients with CMM in a Swedish population.

Methods

We undertook a population-based study of 5850 CMM patients in two Swedish health care regions during 1996-2005. We used flexible parametric cure models to estimate cure proportions and median survival times (MSTs) of uncured by stage, sex, age and anatomical site.

Results

Disease stage at diagnosis was the most important factor for the probability of cure, with a cure proportion of approximately 1.0 for stage IA. While the probability of cure decreased with older age, the influence of age was smaller on the MST of uncured. Differences in prognosis between males and females were mainly attributed to differences in cure as opposed to differences in MST of uncured.

Conclusions

This population-based study showed approximately 100% cure among stage IA disease. Almost 50% of patients had stage IA disease and the high cure proportion for this large patient group is reassuring.