A Proliferative Burst during Preadolescence Establishes the Final Cardiomyocyte Number
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- 作者：Nawazish Naqvi1 ; 8 ; Ming Li2 ; 8 ; John W. Calvert3 ; Thor Tejada1 ; Jonathan P. Lambert3 ; Jianxin Wu2 ; Scott H. Kesteven2 ; Sara R. Holman2 ; Torahiro Matsuda1 ; Joshua D. Lovelock1 ; Wesley W. Howard1 ; Siiri E. Iismaa2 ; 7 ; Andrea Y. Chan2 ; Brian H. Crawford4 ; 5 ; Mary B. Wagner4 ; 5 ; David I.K. Martin6 ; David J. Lefer3 ; Robert M. Graham2 ; 7 ; b.graham@victorchang.edu.au" class="auth_mail ; Ahsan Husain1 ; ahusai2@emory.edu" class="auth_mail
- 刊名：Cell
- 出版年：8 May 2014
- 年：2014
- 卷：157
- 期：4
- 页码：795-807
- 全文大小：4482 K
文摘
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Murine cardiomyocytes continue to proliferate well after the neonatal period
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A proliferative burst in preadolescence establishes the final cardiomyocyte number
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Proliferation is initiated by the thyroid hormone/IGF-1/IGF-1-R/Akt pathway
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Persistence of cardiomyocyte proliferation improves outcomes after cardiac injury