Influence of Adaptive Statistical Iterative Reconstruction on coronary plaque analysis in coronary computed tomography angiography

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• 作者：Helle Precht^a ; ^b ; ^{hepr@ucl.dk" class="auth_mail" title="E-mail the corresponding author} ; ^{hellepan@hotmail.com" class="auth_mail" title="E-mail the corresponding author} ; Pieter H. Kitslaar^c ; ^d ; Alexander Broersen^c ; Jouke Dijkstra^c ; Oke Gerke^e ; ^f ; Jesper Thygesen^g ; Kenneth Egstrup^a ; Jess Lambrechtsen^a
• 关键词：Coronary CTA ; Iterative reconstructions ; ASIR ; Plaque analysis ; Radiation dose reduction
• 刊名：Journal of Cardiovascular Computed Tomography
• 出版年：2016
• 出版时间：November-December 2016
• 年：2016
• 卷：10
• 期：6
• 页码：507-516
• 全文大小：1531 K

文摘

The purpose of this study was to study the effect of iterative reconstruction (IR) software on quantitative plaque measurements in coronary computed tomography angiography (CCTA).

Methods

Thirty patients with a three clinical risk factors for coronary artery disease (CAD) had one CCTA performed. Images were reconstructed using FBP, 30% and 60% adaptive statistical IR (ASIR). Coronary plaque analysis was performed as per patient and per vessel (LM, LAD, CX and RCA) measurements. Lumen and vessel volumes and plaque burden measurements were based on automatic detected contours in each reconstruction. Lumen and plaque intensity measurements and HU based plaque characterization were based on corrected contours copied to each reconstruction.

Results

No significant changes between FBP and 30% ASIR were found except for lumen- (−2.53 HU) and plaque intensities (−1.28 HU). Between FBP and 60% ASIR the change in total volume showed an increase of 0.94%, 4.36% and 2.01% for lumen, plaque and vessel, respectively. The change in total plaque burden between FBP and 60% ASIR was 0.76%. Lumen and plaque intensities decreased between FBP and 60% ASIR with −9.90 HU and −1.97 HU, respectively. The total plaque component volume changes were all small with a maximum change of −1.13% of necrotic core between FBP and 60% ASIR.

Conclusions

Quantitative plaque measurements only showed modest differences between FBP and the 60% ASIR level. Differences were increased lumen-, vessel- and plaque volumes, decreased lumen- and plaque intensities and a small percentage change in the individual plaque component volumes.