Role of complement in host-microbe homeostasis of the periodontium

详细信息    查看全文

• 作者：George Hajishengallis ; Toshiharu Abe ; Tomoki Maekawa ; Evlambia Hajishengallis ; John D. Lambris
• 关键词：Complement ; C5a receptor ; Periodontitis ; Dysbiosis ; Porphyromonas gingivalis
• 刊名：Seminars in Immunology
• 出版年：2013
• 出版时间：February, 2013
• 年：2013
• 卷：25
• 期：1
• 页码：65-72
• 全文大小：1492 K

文摘

Complement plays a key role in immunity and inflammation through direct effects on immune cells or via crosstalk and regulation of other host signaling pathways. Deregulation of these finely balanced complement activities can link infection to inflammatory tissue damage. Periodontitis is a polymicrobial community-induced chronic inflammatory disease that can destroy the tooth-supporting tissues. In this review, we summarize and discuss evidence that complement is involved in the dysbiotic transformation of the periodontal microbiota and in the inflammatory process that leads to the destruction of periodontal bone. Recent insights into the mechanisms of complement involvement in periodontitis have additionally provided likely targets for therapeutic intervention against this oral disease.