Enhancer of Rudimentary Cooperates with Conserved RNA-Processing Factors to Promote Meiotic mRNA Decay and Facultative Heterochromatin Assembly
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- 作者：Tomoyasu Sugiyama1 ; Gobi Thillainadesan1 ; Venkata R. Chalamcharla1 ; Zhaojing Meng2 ; Vanivilasini Balachandran1 ; Jothy Dhakshnamoorthy1 ; Ming Zhou2 ; Shiv I.S. Grewal1 ; grewals@mail.nih.gov" class="auth_mail" title="E-mail the corresponding author
- 刊名：Molecular Cell
- 出版年：2016
- 出版时间：3 March 2016
- 年：2016
- 卷：61
- 期：5
- 页码：747-759
- 全文大小：3038 K
文摘
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Erh1 stoichiometrically interacts with Mmi1 to form a complex called EMC
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EMC engages MTREC and CCR4-NOT to assemble facultative heterochromatin
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Ccr4 cooperates with Pir2/ARS2 to trigger RNAi-mediated facultative heterochromatin
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Erh1 and CCR4-NOT promote rDNA silencing and the maintenance of rDNA integrity