Systematic development of a gastroretentive fixed dose combination of lamivudine and zidovudine for increased patient compliance

详细信息    查看全文

• 作者：Bhupinder Singh^a ; ^b ; ^{bsbhoop@yahoo.com} ; ^{bsbhoop@pu.ac.in} ; Babita Garg^a ; Rahul Bhatowa^a ; Rishi Kapil^a ; Sumant Saini^a ; Sarwar Beg^a
• 关键词：Floating ; Bioadhesive ; Controlled release ; Design of experiments ; HAART ; Quality by design
• 刊名：Journal of Drug Delivery Science and Technology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：37
• 期：Complete
• 页码：204-215
• 全文大小：2673 K
• 卷排序：37

文摘

Development of gastroretentive fixed dose combination of lamivudine and zidovudine. Systematic optimization performed employing FCCD. Bilayer tablets characterized for bioadhesive strength, buoyancy time and drug release characteristics. In vivo gamma scintigraphy confirmed gastric retention of bilayer tablet up to 5 h.