Immunopathologic effects of scorpion venom on hepato-renal tissues: Involvement of lipid derived inflammatory mediators
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- 作者：Amal Lamraoui ; Sonia Adi-Bessalem ; Fatima Laraba-Djebari ; flaraba@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; flaraba@usthb.dz" class="auth_mail" title="E-mail the corresponding author
- 关键词：Aah ; Androctonus australis hector scorpion ; ALP ; alkaline phosphatase ; AST ; aspartate aminotransferase ; CEL ; celecoxib ; COX ; cyclooxygenase ; DEX ; dexamethasone ; EPO ; Eosinophile peroxidase ; GSH ; glutathione ; ICAM-1 ; Inter Cellular Adhesion Molecule ; INDO ; indomethacin ; IL-8 ; interleukin 8 ; IL-6 ; interleukin 6 ; MDA ; malondialdehyde ; MPO ; myeloperoxidase ; NF-kB ; nuclear factor-Kb ; NMRI ; naval Medical Research Institute ; NO ; nitric oxide ; PGE2 ; prostaglandin E2 ; PGH2 ; prostaglandin H2 ; PLA2 ; phosph
- 刊名：Experimental and Molecular Pathology
- 出版年：2015
- 出版时间：October 2015
- 年：2015
- 卷：99
- 期：2
- 页码：286-296
- 全文大小：1707 K
文摘
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We evaluated the immunopathologic effects of scorpion venom on hepatorenal tissues.
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An inflammatory response with alteration of liver and kidney tissues were observed.
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We studied the involvement of cyclooxygenase pathways and phospholipase A2.
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Liver inflammation was a result of combination effects of PLA2-derived products.
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The cyclooxygenase 2 pathway was more activated in the renal tissue inflammation.