Determining the safety of enoxaparin prophylaxis in critically ill patients with severe renal insufficiency - The PACER pilot study
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- 作者：Lana A. Castelluccia ; lcastellucci@toh.on.ca" class="auth_mail" title="E-mail the corresponding author ; Joseph Shawa ; Antonio Giulivib ; Cedrick Edwardsa ; Marc Carriera ; Rakesh Patela
- 关键词：VTE ; venous thromboembolism ; CrCl ; creatinine clearance ; DVT ; deep vein thrombosis ; LMWH ; low-molecular-weight heparin ; PACER ; Prophylactic AntiCoagulation with Enoxaparin in Renal insufficiency ; ICU ; intensive care unit ; INR ; international normalized ratio ; PTT ; partial thromboplastin time ; PE ; Pulmonary Embolism ; ACCP ; American College of Chest Physicians ; AKI ; acute kidney injury ; APACHE II ; Acute Physiology and Chronic Health Evaluation II
- 刊名：Thrombosis Research
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：144
- 期：Complete
- 页码：69-71
- 全文大小：162 K
文摘
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Critically ill patients with severe renal insufficiency are at risk for venous thromboembolism.
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These patients are at risk for anticoagulation bioaccumulation.
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We achieved the minimum monthly recruitment target; a larger study is likely feasible.
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Bioaccumulation of enoxaparin was not demonstrated.