A chimeric protein composed of NuMA fused to the DNA binding domain of LANA is sufficient for the ori-P-dependent DNA replication

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• 作者：Eriko Ohsaki ; Keiji Ueda ; ^{kueda@virus.med.osaka-u.ac.jp}
• 刊名：Virology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：500
• 期：Complete
• 页码：190-197
• 全文大小：978 K
• 卷排序：500

文摘

KSHV replication in latency depends on LANA localization to the nuclear matrix. LANA DBD was fused with NuMA, a nuclear matrix protein, at the N- and C-terminus. NuMA-DBD was in the nuclear matrix and supported the ori-P dependent replication. LANA in the nuclear matrix should be important for the KSHV replication in latency.