Tankyrase-1 Ankyrin Repeats Form an Adaptable Binding Platform for Targets of ADP-Ribose Modification
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- 作者：Travis Eisemann1 ; Michael McCauley1 ; Marie-France Langelier1 ; 2 ; Kushol Gupta3 ; Swati Roy1 ; Gregory D. Van Duyne3 ; John M. Pascal1 ; 2 ; 4 ; john.pascal@umontreal.ca" class="auth_mail" title="E-mail the corresponding author
- 刊名：Structure
- 出版年：2016
- 出版时间：4 October 2016
- 年：2016
- 卷：24
- 期：10
- 页码：1679-1692
- 全文大小：6435 K
文摘
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X-ray structure of three consecutive Tankyrase-1 (TNKS) ankyrin repeat clusters (ARCs)
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SAXS and sedimentation analysis of the complete TNKS ankyrin repeat domain (ARC1–5)
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Binding analysis indicates specific ARC pairs engage bivalent binding partner Axin1
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Both rigid and flexible ARC connections form an adaptable TNKS binding platform