Quality-of-life after radiotherapy for advanced laryngeal cancer: Results of a phase III trial of the Dutch Head and Neck Society

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• 作者：Geert O. Janssens^a ; ^b ; ^{g.o.r.janssens@umcutrecht.nl" class="auth_mail" title="E-mail the corresponding author} ; Johannes A. Langendijk^c ; Chris H. Terhaard^b ; Patricia A. Doornaert^d ; Piet van den Ende^e ; Martin A. de Jong^f ; Robert P. Takes^g ; Paul N. Span^a ; Johannes H. Kaanders^a
• 关键词：Quality-of-life ; Laryngeal cancer ; Accelerated radiotherapy ; ARCON ; Randomized trial
• 刊名：Radiotherapy and Oncology
• 出版年：2016
• 出版时间：May 2016
• 年：2016
• 卷：119
• 期：2
• 页码：213-220
• 全文大小：883 K

文摘

To report on health-related quality-of-life (HRQoL) of patients with laryngeal cancer, treated in a randomized trial comparing accelerated radiotherapy with carbogen and nicotinamide (ARCON) against accelerated radiotherapy alone (AR).

Material/methods

HRQoL was assessed using the HRQoL Questionnaire-C30 (QLQ-C30) and the Head & Neck cancer module (QLQ-H&N35) at baseline, at completion of radiotherapy and at 6, 12, and 24 months post-baseline.

Results

From 269/345 patients (AR: 136/174; ARCON: 133/171) data on HRQoL were available for analysis. Moderate to severe clinical impact of the treatment was observed for nearly all items of the QLQ-C30 and QLQ-H&N35 between baseline and end-of-treatment. At 6 months, scores returned to baseline level with exception of dry mouth, sticky saliva, and taste/smell. No difference between AR and ARCON was observed. At 2 years from baseline, the percentage of patients reporting moderate to severe complaints of dry mouth, sticky saliva, or changes in taste/smell was 30%, 22% and 18%, respectively, while the majority of patients had no or few complaints of swallowing (79%) or speech (64%).

Conclusions

With accelerated radiotherapy, high local tumor control was obtained while maintaining good speech and swallowing function. Long-term dry mouth, sticky saliva and changes in taste/smell are limited to one quarter of patients. (ClinicalTrials.gov number, NCT00147732).