Nano-confinement of acetaminophen into porous mannitol through adsorption method
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- 作者：Morteza Saffari ; morteza.saffari@sydney.edu.au" class="auth_mail" title="E-mail the corresponding author ; Amirali Ebrahimi ; Timothy Langrish
- 关键词：Adsorption ; Templating process ; High-porosity mannitol ; Spray drying ; Acetaminophen
- 刊名：Microporous and Mesoporous Materials
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：227
- 期：Complete
- 页码：95-103
- 全文大小：2029 K
文摘
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Developing a new production process for high-porosity mannitol particles.
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Successful drug-loading of porous mannitol through an adsorption method.
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Low variability for the drug content for the finished products.
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Considerable effect of adsorption method on release rate of drug-loaded mannitol.
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Significant enhancement in the tableting properties of the final formulation.