Oral perineurioma: clinicopathologic features from two cases and review of literature

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• 作者：Wagner Gomes da Silva ; DDS ; MSc ; PhD Student^a ; Marisol Martí ; nez Martí ; nez ; DDS ; PhD^a ; Á ; guida Maria Menezes Aguiar Miranda ; DDS ; MSc^b ; Roberto Bastos Silva ; DDS^c ; Henrique Martins da Silveira ; DDS ; PhD^c ; Oslei Paes de Almeida ; DDS ; PhD^a ; Fá ; bio Ramô ; a Pires ; DDS ; PhD^b ; ^d ; ^{Ramoafop@yahoo.com}
• 刊名：Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：123
• 期：3
• 页码：e91-e98
• 全文大小：3007 K
• 卷排序：123

文摘

The present study reports two cases of oral perineuriomas, including a clinicopathologic review of the 39 published cases (17 intraneural and 22 extraneural perineuriomas) in the English language literature. In the first case, the tumor occurred in an 84-year-old male as a painless, asymptomatic, 20-mm submucosal nodule on the right lower mucobuccal fold near to the premolar area. In the second case, a 46-year-old female presented with a painless, 25-mm, slow-growing, fibrous, pedunculated nodule on the right buccal mucosa. In the first case, the tumor was composed of spindle cells arranged in a storiform pattern, classified as intraneural perineurioma; and in the second, it was an extraneural perineurioma, showing a whorled myxoid stroma. Immunohistochemical analysis confirmed the diagnosis by showing positivity for vimentin, EMA, and Glut-1 in case 1 and EMA, Glut-1, Claudin-1, and CD34 (focally) in case 2. Complete surgical removal was performed for both tumors, and there was no evidence of local recurrence after a long-term follow-up.